Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl benzyl(phenyl)carbamodithioate | - |
Human immunodeficiency virus 1 | |
2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl dibenzylcarbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[(2,3,4-trichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
2-[(2,4-dichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[(2,4-dimethylphenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
2-[(2-methoxy-5-methylphenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[(3-cyanophenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[(3-cyanophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | - |
Human immunodeficiency virus 1 | |
2-[4-benzyl-5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]pyridine | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
2-[4-benzyl-5-[(pyridin-4-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-yl]pyridine | - |
Human immunodeficiency virus 1 | |
3-(furan-2-yl)-4-(4-methoxybenzyl)-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
3-(furan-2-yl)-4-phenyl-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
4-([[4-benzyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | - |
Human immunodeficiency virus 1 | |
4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
4-benzyl-3-(benzylsulfanyl)-5-(furan-2-yl)-4H-1,2,4-triazole | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
4-benzyl-3-(benzylsulfanyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
4-benzyl-3-(benzylsulfanyl)-5-phenyl-4H-1,2,4-triazole | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
4-benzyl-3-(furan-2-yl)-5-[(4-methoxybenzyl)sulfanyl]-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(furan-2-yl)-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | - |
Human immunodeficiency virus 1 | |
4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole | inhibitor indentified by FRET-based high-throughput screening assay | Human immunodeficiency virus 1 | |
additional information | identification and evaluation of thiocarbamate and triazole inhibitors targeting RNase H activity of HIV reverse transcriptase, overview | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Human immunodeficiency virus 1 | - |
HIV-1 | - |
Synonyms | Comment | Organism |
---|---|---|
ribonuclease H | - |
Human immunodeficiency virus 1 |
RNase H | - |
Human immunodeficiency virus 1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | |
0.00021 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.00021 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.001 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-phenyl-4H-1,2,4-triazole | |
0.001 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.001 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole | |
0.001 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-phenyl-4H-1,2,4-triazole | |
0.001 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.001 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.0012 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-(furan-2-yl)-4H-1,2,4-triazole | |
0.0012 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-(benzylsulfanyl)-5-(furan-2-yl)-4H-1,2,4-triazole | |
0.0017 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 2-[4-benzyl-5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]pyridine | |
0.0017 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[4-benzyl-5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]pyridine | |
0.0019 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 2-[(2,4-dimethylphenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | |
0.0019 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(2,4-dimethylphenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | |
0.0026 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[4-benzyl-5-[(pyridin-4-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-yl]pyridine | |
0.0028 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(furan-2-yl)-4H-1,2,4-triazole | |
0.0033 | - |
pH 8.0, 25°C | Human immunodeficiency virus 1 | 2-[(2,3,4-trichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | |
0.0033 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl dibenzylcarbamodithioate | |
0.0038 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-(furan-2-yl)-5-[(4-methoxybenzyl)sulfanyl]-4H-1,2,4-triazole | |
0.004 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-([[4-benzyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine | |
0.0047 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(3-cyanophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | |
0.0047 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 3-(furan-2-yl)-4-phenyl-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole | |
0.0058 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(2,4-dichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate | |
0.0059 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole | |
0.006 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole | |
0.0065 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 3-(furan-2-yl)-4-(4-methoxybenzyl)-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole | |
0.0083 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(2-methoxy-5-methylphenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate | |
0.0114 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-[(3-cyanophenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate | |
0.0266 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl benzyl(phenyl)carbamodithioate | |
0.2 | - |
pH not specified in the publication, temperature not specified in the publication | Human immunodeficiency virus 1 | 4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine |